Acute restraint stress impairs histamine type 2 receptor ability to increase the excitability of medium spiny neurons in the nucleus accumbens

Histamine, a monoamine implicated in stress-related arousal states, is synthesized in neurons exclusively located in the hypothalamic tuberomammillary nucleus (TMN) from where they diffusely innervate striatal and mesolimbic networks including the nucleus accumbens (NAc), a vital node in the limbic loop.Since histamine-containing TMN neuron output

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Influence of human-induced land use change on hydrological processes in semi-humid and semi-arid region: A case in the Fenhe River Basin

Study Region: The Fenhe River Basin (FRB) is an important tributary of the Yellow River Basin and locate in a semi-arid and semi-humid region in northwest China.Over the past four decades, significant anthropogenic activities have resulted in significant land use and land cover change (LUCC) that have markedly impacted hydrological processes in FRB

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ISTSOS, SENSOR OBSERVATION MANAGEMENT SYSTEM: A REAL CASE APPLICATION OF HYDRO-METEOROLOGICAL DATA FOR FLOOD PROTECTION

istSOS (Istituto scienze della Terra Sensor Observation Service) is an implementation of the Sensor Observation Service standard from Open Geospatial Consortium (OGC).The development of istSOS started in 2009 in order to provide a simple implementation of the Sensor Observation Service (SOS) standard for the management, provision and integration of

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Best practices for germline variant and DNA methylation analysis of second- and third-generation sequencing data

Abstract This comprehensive review provides insights and suggested strategies for the analysis of germline variants using second- and third-generation sequencing technologies (SGS and TGS).It addresses the critical stages of data processing, starting from alignment and preprocessing to quality control, variant calling, and the removal of artifacts.

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